Origin	China
Brand Name	KH

Melissa officinalis L.

Melissa officinalis L. is also called Lemon Balm, Balm, Bea Balm, belongs to Labiatae

Melissa officinalis extract is of value in the management of mild to moderate Alzheimer’s disease and has a positive effect on agitation in such patients. Alzheimer’s disease（AD） is the leading cause of dementia in mid to late life and is estimated to affect approximately 20 million people worldwide. There are considerable financial, social, and emotional costs associated with the burden of caring for patients with this disease. (Journal of Neurology, Neurosurgery & Psychiatry, Volume 74(7), July 2003, pp 863-866).

In this respect, herbal medicines may be a new avenue of treatment for Alzheimer’s disease. on the basis of a retrospective review of the historical role of various European herbs in the improvement of cognition, and in particular memory—that Melissa officinalis and another herb in the labiatae family, Salvia officinalis, might provide a natural treatment for Alzheimer’s disease. Melissa officinalis comes from Europe and is now grown all over the world. As well as having soothing and carminative effects, it also has anxiolytic and sedative/hypnotic actions. It has been reported that Melissa officinalis has acetylcholine receptor activity in the central nervous system, with both nicotinic and muscarinic binding properties.Moreover, a recent study showed that this herb modulates mood and cognitive performance during acute administration in healthy young volunteers. No side effects or symptoms of toxicity have been reported with its use.
We undertook the present study to test the efficacy and safety of a fixed dose of Melissa officinalis over a four month period in patients with mild to moderate Alzheimer’s disease, using a double blind, randomised, placebo controlled trial design.
The plant extract was prepared as 1:1 in 45% alcohol. The extract was standardised to contain at least 500 µg citral/ml.
Melissa officinalis water extracts were found to contain Rosmarinus acid substances responsible for immunomodulation of several complement-dependent inflammatory processes with a major effect on the C5 convertase enzyme.
It has been suggested—on the basis of a retrospective review of the historical role of various European herbs in the improvement of cognition, and in particular memory—that Melissa officinalis and another herb in the labiatae family, Salvia officinalis, might provide a natural treatment for Alzheimer’s disease. Melissa officinalis comes from Europe and is now grown all over the world. As well as having soothing and carminative effects, it also has anxiolytic and sedative/hypnotic actions. It has been reported that Melissa officinalis has acetylcholine receptor activity in the central nervous system, with both nicotinic and muscarinic binding properties. Moreover, a recent study showed that this herb modulates mood and cognitive performance during acute administration in healthy young volunteers. No side effects or symptoms of toxicity have been reported with its use. The side effects associated with Melissa in this study were generally those expected from cholinergic stimulation, and are similar to those reported with cholinesterase inhibitors.
It helps to relieve headache, improve stomach function, help digestion, anti-depression, and help refreshment.